KMID : 0895420130230030169
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Journal of Korean Society of Occupational and Enviromental Hygiene 2013 Volume.23 No. 3 p.169 ~ p.176
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Review of Respiratory Disease and Hazardous Agents Caused by the Use of Biocide in Metalworking Operations
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Park Dong-Uk
Ko Ye-Ji Yoon Chung-Sik
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Abstract
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Objectives: The aim of this study is to critically review the health effects of not only direct exposure to biocide, but also indirect exposure to by-product hazardous agents generated through the use of biocide in metalworking operations.
Methods: An extensive literature review was conducted of studies reporting on respiratory disease cases, particularly hypersensitivity pneumonitis(HP), in environments using water-soluble metalworking fluids(MWFs). Keyword search terms included ¡®etalworking fluids¡¯ ¡®achining fluids¡¯ ¡®etalworking operation¡¯¡®achining operation¡¯and ¡®iocide¡¯ which were also used in combination. Additional articles were identified in references cited in the articles reviewed.
Results: Several of the field, epidemiological and experimental studies reviewed assumed that the symptoms and signs typical of HP developed in machinists who handled water-soluble MWF could be caused by inhalation exposure to nontuberculous mycobacteria(NTM). Most NTM are known to be not only resistant to both biocide and disinfectant, but also to have acid-fast cell walls that are highly antigenic. The presence or persistence of the Mycobacterium species, referred to as NTM, in metalworking fluid-using operations may be caused by NTM contamination in either the natural water or tap water that is used to dilute the base oil and additives for water-soluble MWFs. This hypothesis that NTM contamination in water-soluble MWFs is a causative agent of HP has high biologic plausibility, such as antigenic property, hydrophobicity and small diameter(< 5 um).
Conclusions: Aerosolized mycobacteria colonized from MWF are likely to be causing the HP. Inhalation exposure to mycobacteria should be considered as a possible cause for the development of HP.
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KEYWORD
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water-soluble metalworking fluids, biocide, nontuberculous mycobacteria (NTM), triazine
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